Season One

Switched at Birth, a one-hour scripted drama, tells the story of two teenage girls who discover they were accidentally switched as newborns in the hospital. Bay Kennish grew up in a wealthy family with two parents and a brother, while Daphne Vasquez, who lost her hearing at an early age due to a case of meningitis, grew up with a single mother in a working-class neighborhood. Things come to a dramatic head when both families meet and struggle to learn how to live together for the sake of the girls.

Switched at Birth stars newcomer Katie Leclerc as Daphne Vasquez; Vanessa Marano (Gilmore Girls) as Bay Kennish; Constance Marie (George Lopez) as Regina Vasquez; D.W. Moffett (Friday Night Lights) as John Kennish; Lea Thompson (Back to the Future, Caroline in the City) as Kathryn Kennish; and Lucas Grabeel (High School Musical) as Toby Kennish.

Lizzy Weiss (Blue Crush), Paul Stupin (Make It or Break It) and John Ziffren (Melissa & Joey, Make It or Break It) serve as executive producers.

Main
as Daphne Vasquez as Bay Kennish as Toby Kennish asEmmett Bledsoe as Regina Vasquez as John Kennish as Kathryn Kennish
 * Katie Leclerc
 * Vanessa Marano
 * Lucas Grabeel
 * Sean Berdy
 * Constance Marie
 * D.W. Moffett
 * Lea Thompson

Recurring
as Adrianna Vasquez (15 episodes) as Simone Sinclair (15 episodes) as James "Wilke" Wilkerson III (14 episodes) as Melody Bledsoe (13 episodes) as Angelo Sorrento (12 episodes) as Craig Tebbe (8 episodes) as Jeff Reycraft (7 episodes) as Patrick (7 episodes) as Zarra (7 episodes) as Tyler "Ty" Mendoza (6 episodes) as Amanda Burke (6 episodes) as Travis Barnes (6 episodes) as Coach Medlock (6 episodes)
 * Ivonne Coll
 * Maiara Walsh
 * Austin Butler
 * Marlee Matlin
 * Gilles Marini
 * Sam Page
 * Justin Bruening
 * Christopher Wiehl
 * Tania Raymonde
 * Blair Redford
 * Meeghan Holaway
 * Ryan Lane
 * Brandon Bell

Cont.
as Cameron Bledsoe (4 episodes) as Liam Lupo (4 episodes) as Nikki Papagus (4 episodes) as Ms. Rose (4 episodes) as Scuba (4 episodes) as Geraldo (4 episodes) as Bruce (3 episodes) as Denise (3 episodes) as Dale (3 episodes) as Cheves (3 episodes) as Olivia (3 episodes) as Mouse (3 episodes) as Alex Rainford (2 episodes) as Tina Choi (2 episodes) as Mr. Thatcher (2 episodes) as Monica (2 episodes)
 * Anthony Natale
 * Charles Michael Davis
 * Cassi Thomson
 * Carlease Burke
 * Manish Dayal
 * Oliver Muirhead
 * Jason Brooks
 * Tammy Townsend
 * Robin Thomas
 * Aaron Todd Kessee
 * TL Forsberg
 * Mario Ardila Jr.
 * Mat Vairo
 * Tina Huang
 * Steven Connor
 * Natalie Amenula

Trivia

 * This season has a larger amount of episodes than all of other seasons.
 * This season only has one volume of first 10 episodes for DVD.
 * It's probably because of its low rating and financial issues, but it's not confirmed yet.
 * Sean Berdy, who plays Emmett Bledsoe, is only one who absent the 16th episode, and the rest of main stars are appeared in this entire season.